Restu Apriena Putri, Tris Eryando



The Effect of Antenatal Depression to Birth Outcomes: A Systematic Review

Mental health problems is an important public health challenge. There are 10% of pregnant women with mental disorders, especially depression. Depression affects adverse birth outcomes such as premature birth, low birth weight, low APGAR score, small head circumference and small for gestational (SGA). Objective: The purpose of this study is to determine the effect of antenatal depression on birth outcomes. Method: This study use a systematic review method using PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocole) 2009. Results: From 836 documents, 5 studies were selected from Vietnam, Pakistan, Malaysia, The United States and Australia. 4 studies is a prospective cohort study design and 1 cross sectional study showing the negative effects of antenatal depression on birth outcomes. Conclusion: Antenatal depression has a negative impact on birth outcomes by increasing the risk of preterm birth (<37 weeks), increasing the risk of LBW birth (2500 grams), increasing the risk of a low APGAR score, and increasing the risk of having a small for gestational (SGA) baby.


pregnant women; antenatal depression; birth outcomes

Full Text:



Bennett, H. A., Einarson, A., Taddio, A., Koren, G., & Einarson, T. R. (2004, April). Prevalence of depression during pregnancy: Systematic review. Obstetrics and Gynecology, Vol. 103, pp. 698–709. https://doi.org/10.1097/01.AOG.0000116689.75396.5f

Dadi, A. F., Miller, E. R., Bisetegn, T. A., & Mwanri, L. (2020). Global burden of antenatal depression and its association with adverse birth outcomes: An umbrella review. BMC Public Health, 20(1). https://doi.org/10.1186/s12889-020-8293-9

Eastwood, J., Ogbo, F. A., Hendry, A., Noble, J., & Page, A. (2017). The impact of antenatal depression on perinatal outcomes in Australian women. PLoS ONE, 12(1). https://doi.org/10.1371/journal.pone.0169907

Goedhart, G., Snijders, A. C., Hesselink, A. E., Van Poppel, M. N., Bonsel, G. J., & Vrijkotte, T. G. M. (2010). Maternal depressive symptoms in relation to perinatal mortality and morbidity: Results from a large multiethnic cohort study. Psychosomatic Medicine, 72(8), 769–776. https://doi.org/10.1097/PSY.0b013e3181ee4a62

Grote, N. K., Bridge, J. A., Gavin, A. R., Melville, J. L., Iyengar, S., & Katon, W. J. (2010). A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction. Archives of General Psychiatry, 67(10), 1012–1024. https://doi.org/10.1001/archgenpsychiatry.2010.111

Li, D., Liu, L., & Odouli, R. (2009). Presence of depressive symptoms during early pregnancy and the risk of preterm delivery: a prospective cohort study †. Human Reproduction, 24(1), 146–153. https://doi.org/10.1093/humrep/den342

Mongan, D., Lynch, J., Hanna, D., Shannon, C., Hamilton, S., Potter, C., … Mulholland, C. (2019). Prevalence of self-reported mental disorders in pregnancy and associations with adverse neonatal outcomes: a population-based cross-sectional study. BMC Pregnancy and Childbirth, 19(1). https://doi.org/10.1186/s12884-019-2572-4

Nasreen, H. E., Kabir, Z. N., Forsell, Y., & Edhborg, M. (2010). Low birth weight in offspring of women with depressive and anxiety symptoms during pregnancy: Results from a population based study in Bangladesh. BMC Public Health, 10, 515. https://doi.org/10.1186/1471-2458-10-515

Nasreen, H. E., Pasi, H. B., Rifin, S. M., Aris, M. A. M., Rahman, J. A., Rus, R. M., & Edhborg, M. (2019). Impact of maternal antepartum depressive and anxiety symptoms on birth outcomes and mode of delivery: A prospective cohort study in east and west coasts of Malaysia. BMC Pregnancy and Childbirth, 19(1). https://doi.org/10.1186/s12884-019-2349-9

Orr, S. T., James, S. A., & Prince, C. B. (2002). Maternal Prenatal Depressive Symptoms and Spontaneous Preterm Births among African-American Women in Baltimore, Maryland. American Journal of Epidemiology, 156(9), 797–802. https://doi.org/10.1093/aje/kwf131

Saeed, A., Raana, T., Saeed, A. M., & Humayun, A. (2016). Effect of antenatal depression on maternal dietary intake and neonatal outcome: A prospective cohort. Nutrition Journal, 15(1). https://doi.org/10.1186/s12937-016-0184-7

Szegda, K., Bertone-Johnson, E. R., Pekow, P., Powers, S., Markenson, G., Dole, N., & Chasan-Taber, L. (2017). Depression During Pregnancy and Adverse Birth Outcomes Among Predominantly Puerto Rican Women. Maternal and Child Health Journal, 21(4), 942–952. https://doi.org/10.1007/s10995-016-2195-6

Szegda, K., Markenson, G., Bertone-Johnson, E. R., & Chasan-Taber, L. (2014). Depression during pregnancy: A risk factor for adverse neonatal outcomes? A critical review of the literature. Journal of Maternal-Fetal and Neonatal Medicine, 27(9), 960–967. https://doi.org/10.3109/14767058.2013.845157

Van Ngo, T., Gammeltoft, T., Nguyen, H. T. T., Meyrowitsch, D. W., & Rasch, V. (2018). Antenatal depressive symptoms and adverse birth outcomes in Hanoi, Vietnam. PLoS ONE, 13(11). https://doi.org/10.1371/journal.pone.0206650

Wado, Y. D., Afework, M. F., & Hindin, M. J. (2014). Effects of maternal pregnancy intention, depressive symptoms and social support on risk of low birth weight: A prospective study from Southwestern Ethiopia. PLoS ONE, 9(5). https://doi.org/10.1371/journal.pone.0096304

WHO. (2015a). THINKING HEALTHY A manual for psychosocial management of perinatal depression WHO generic field-trial version 1.0, 2015 Series on Low-Intensity Psychological Interventions-1.

WHO. (2015b). WHO | Maternal mental health. WHO.

Wichman, C. L., & Stern, T. A. (2015). Lessons learned at the interface of medicine and psychiatry. Primary Care Companion to the Journal of Clinical Psychiatry, 17(2). https://doi.org/10.4088/PCC.15f01776

DOI: https://doi.org/10.35842/mr.v16i1.300

Article Metrics

Abstract view : 136 View
PDF - 34 View


  • There are currently no refbacks.

Copyright (c) 2021 Medika Respati : Jurnal Ilmiah Kesehatan

Medika Respati : Jurnal Ilmiah Kesehatan indexed by:

   Crossref  Google Scholar